Cosmology
The Universe
Endless: The universe is an unimaginably sparse void of infinite space, littered with stars, planets, and various detritus.
Limited: The physical universe in your campaign world might be smaller in scope yet far more fanciful. For example, Norse cosmology describes nine worlds connected by an immense ash tree. How does that fit into your science fantasy story?
Bizarre: Sometimes the universe is more complex than the previous two categories, or possibly nested within multiple realities and timelines. What if the universe the PCs first know is in fact a magical or technological simulation of such complexity that its inhabitants are unaware that they exist as an artificial consciousness? Perhaps this is even where your PCs first meet before transitioning into another reality.
Composition of Space
Celestial Spheres: The ancient Greeks posited that planets, stars, and more were embedded like jewels within celestial orbs of quintessence nested within one another. Perhaps celestial bodies in your campaign are really massive aeon stones, or something else unique to your setting.
Endless Sky: What if the blue sky overhead extended outward forever? One need only fly high enough and far enough to reach another world, using environmental protections to defend against the frigid cold. In such a campaign, space might not carry the hazards of radiation and breathlessness, but it might be more like a vast sea where ships and people flow with the currents and explore the depths.
Vacuum: In conventional astronomy, outer space is an immense void existing in a near-perfect vacuum. The immeasurable expanse of space is home to everything in the Universe and requires starships to both navigate and survive. You might incorporate hard sci-fi details to make adventures in outer space feel more believable and perilous.
The Barycenter
Dyson Sphere: Perhaps a solar system has been enclosed in an artificial structure designed to harness the power of the sun. The residents have long since forgotten, and escaping the sphere is an eventual goal of the campaign.
Geocentric: What if another world was the center of the known universe? Perhaps it's the primary game world, or perhaps it's the campaign's final destination.
Heliocentric: Physics dictates that all planets in a system orbit the sun, and the center of mass of a galaxy orbits a black hole. Some systems might have more than one star.